Description
The latest volume in this series covers recent research in molecular biology and biochemistry. It provides information on such rapidly expanding areas as manipulating monoclonal antibodies, diseases of abnormal antigen receptor formation, and the molecular mechanisms of autoimmunity. It will be useful to researchers in molecular biology, immunology, and biochemistry who need to keep up with new developments in this field.Table of ContentPart 1 Antigen-specific receptors: mechanism and control of 1g heavy chain class-switching, Frederick W.Alt; origin and receptor diversity of epithelium associated cells, James P.Allison; control of T cell development by the T cell receptor for antigen, Harald Von Boechmer. Part 2 Diseases of abnormal antigen receptor formation: mechanism of DNA rearrangement in antigen receptor genes, Hitoshi Sakano; abnormal antigen receptor formation in normal, ataxiatelangiectasia, and malignant lymphocytes, Illan R.Kirsch; chromosomal translocations in T cells and developmentally regulated genes, Terence H.Rabbits. Part 3 Receptors, immunological structure and pharmaceutical development: structural studies of ligands and receptors, Mark I.Green; structure/function studies of human class I and class II histocompatability antigens, Don C.Wiley; the major receptor for human rhinovirus, Jeffrey M.Greve; biological properties of genetically engineered antigenic hybirds of polymers and the nature of a human polio virus receptor molecule, Eckard A.Wimmer. Part 4 The Feodor Lynen lecture: super antigens, their functions in health and disease, Phillippa Marrack; selection, tolerance and the T cell repertoire, John W.Kappler. Part 5 The distinguished service award: antibodies - a paradigm for the biology of molecular recognition, Cesar Milstein. Part 6 Molecular mechanisms in autoimmunity: immunoglobulin genes in grave's disease, Bonnie Blomberg; immunogetics of collagen induced and reactive arthritis, Chella S.David; molecular design of agents blocking interactions of T cells with self, Lawrence Steinman. Part 7 Manipulating the monoclonal: rapid cloning of antibody genes from small numbers of cells, James W.Larrick; engineering of antibodies produced in E. coli, Andreas G.Pluckthun; biotechnology and developing countries - Cuba's monoclonal antibody story; Jorge V. Gavilondo-Cowley. Part 8 Disordered regulation of lymphocyte activation: defects in assembly and transduction of human T cell receptors, Cox Terhorst; antisense RNA analyses in lymphocytes - defining new functions for cell surface molecules, Mark L.Tykocinski; new cytotoxic agents created by the fusion of toxin and cell recognition genes, Ira H.Pastan. Part 9 Manipulating the monoclonal: immunotoxins in lymphoma and AIDS, Ellen S. Vitetta; new strategies in biological catalyst design, Peter G.Schultz; constant region mutant and their influence on effector functions, Sherie L.Morrison; the use of bifunctional monoclonal antibodies in diagnosis and therapy, Christopher L.Reading. Part 10 Antigen recognition and lymphocyte activation: molecular basis of immune recognition, Jack L. Strominger; a transgenic model of T cell development, Denis Y.Loh. Part 11 Genetic disorder of surface molecules: genetic control of regulation and disregulation of HLA class II genes, Bernard F. Mach (Part contents).
