Cardiovascular Diseases - Nutritional and Therapeutic Interventions

With cardiovascular disease remaining one of the primary causes of morbidity and mortality worldwide, there is a great need to further understand the molecular basis of this disease class and develop new therapeutic or preventative measures. Cardiovascular Diseases: Nutritional and Therapeutic Interventions presents up-to-date information on the pathobiology of cardiovascular diseases, emphasizing emerging therapeutics and nutritional interventions. The book is divided into four parts: epidemiology, epigenetics, pathobiology, and therapies for cardiovascular diseases.Part I details epidemiological studies, highlighting the extent of the clinical problem. Part II describes the genetic and, primarily, epigenetic modifications associated with cardiovascular disease, including the importance of DNA methylation status and the possibility of early intervention using simple dietary modifications. The text also discusses histone modifications associated with disease and potential therapeutic synthetic and dietary compounds such as resveratrol and garlic. Covering the etiology and pathobiology, part III discusses lipid regulation, micro-RNAs, emerging cell-based therapies, and new receptor targets for therapeutics as well as targeted imaging. It also describes the link between cancer therapies and cardiomyopathy and the potential of vitamin C to ameliorate this effect.Part IV focuses on therapeutic and nutritional interventions, namely, stem cell therapies, emerging nanomedicines, and a wide range of dietary interventions. These include general healthy diets, fruits and vegetables, botanicals, effects of specific compounds such as antioxidants, and discussions on garlic, curcumin, and resveratrol. The text also covers lifestyle factors, emphasizing the importance of stress in the occurrence of and meditation and yoga in the management of cardiovascular disease. This book provides a comprehensive reference for clinicians and scientists, combining epidemiology, prevention, and modern treatment strategies.Table of ContentPart I: Epidemiological Study of Heart Disease. Epidemiology of Cardiovascular Disease. Part II: Epigenetic Modifications in Arterial and Heart Diseases. Epigenetics of Atherosclerosis: Current Insights and Future Perspectives. Genetic and Epigenetic Basis of Myocardial Ischemia and Reperfusion Injury: Protection by Dietary Antioxidants and Chromatin-Modifying Compounds. Attenuation of Myocardial Ischaemia-Reperfusion Injury by Probiotic Bacteria. Part III: Cardiovascular Disease. Lipid Regulation of Cardiac Ion Channels in Heart Disease. Arginine, Tetrahydrobiopterin, and Nitric Oxide in Myocardial Protection. Role of Toll-Like Receptors in Myocardial Ischemia/Reperfusion Injury. Aging, Nutrients, and Endogenous Stem Cell Populations. Intracellular and Extracellular MicroRNAs in Myocardial Angiogenesis. Doxorubicin-Induced Cardiomyopathy and Benefits from Vitamin C. Hypoxic Preconditioning of Stem Cells to Treat Myocardial Infarction. Diabetes-Associated Cardiomyopathy and Cell Therapy. Part IV: Nutritional and Other Therapeutic Interventions for CVD. Pluripotent Stem Cell Therapy for Cardiac Regeneration. Nanotechnology and Cardiovascular Diseases. Heart-Healthy Diet: "The Art and Science of Perfecting the Plate". Nutritional Therapy in the Treatment of Oxidative-Stress-Induced Heart Disease. Therapeutic Strategies for Metabolic Syndrome and Lifestyle-Related Disease. Alcohol and Heart Health: Is the Preconditioning Effect of Wine Drinking Related to Alcohol-Induced Changes in Cellular Fatty Acid Profile? Antioxidative Compounds: Description and Evidence of Clinical Relevance. Garlic in Cardiovascular Health: Winnowing the Fact from Artifacts. Resveratrol Emerges As a Miracle Cardioprotective Phytochemical Polyphenol and Nutraceutical. Potent Beneficial Effects of Vegetables and Fruits of Cardiovascular Diseases. Phosphodiesterase-5 Inhibitors in Cardioprotection. Flaxseed and Its Components in Coronary Artery and Peripheral Vascular Disease. Flaxseed and Blood Pressure. Curcumin and Cardiovascular Diseases. Effect of Fruit and Vegetable Intake on CVD Risk Factors in Humans. Melon for Cardiovascular Health. Botanicals as Angiotensin Converting Enzyme Inhibitors Useful in Hypertension. Yoga, Meditation, and Healthy Heart: Principles and Evidence. Index.Biographical NoteNilanjana Maulik, Ph.D., FAHA, is a professor in the Department of Surgery, University of Connecticut Medical Center, Farmington, Connecticut. She is also a faculty member of the Cell Biology Graduate Program since 2004 at the University of Connecticut Health Center. Professor Maulik’s research focuses on the molecular mechanism of myocardial angiogenesis, ischemia/reperfusion injury, apoptosis, and on the development of cardioprotective strategies, diabetic heart failure, peripheral artery disease, and wound healing. She has published almost 180 original peer-reviewed articles, 35 book chapters, and has edited a book related to epigenetics and human disease.