Human Cytogenetics: Constitutional Analysis v. 1

The study of human chromosomes, at both the microscopic and molecular level, has helped characterize many genetic diseases. As understanding of the etiology and mechanisms of cytogenetic disorders continues to increase, more families at risk for these diseases may be given help through genetic counselling, accurate risk estimation, and prenatal diagnosis. This new edition of Human Cytogenetics: A Practical Approach serves as a fully comprehensive manual of established cytogenetic protocols together with relevant background information. Volume I concentrates entirely on laboratory techniques used in the study and diagnosis of non-malignant chromosome abnormalities. It is an invaluable compendium of basic information and more advanced specialist techniques in cytogenetics.Table of ContentAn introduction to human chromosomes and their analysis, J. Wolstenholme; lymphocyte culture, C.M. Gosden et al; prenatal diagnosis and tissue culture, D.E. Rooney and B.H. Czepulkowski; chromosome staining and banding techniques, P.A. Benn and M.A. Perle;; the application of cytogenetic investigations to clinical practice, J. Wolstenholme and J. Burn; chromosome analysis by non-isotopic in situ hybridization, P. Lichter and T. Cremer; meiotic studies in man, A.S.H. Goldman et al; microscopy, photography and computerized image analysis systems, A.J. Monk; human chromosome analysis by flow cytometry, B.D. Young.