Description
This is a full introductory textbook of pharmacology for students of medicine, dentistry, pharmacy and allied fields. It developed from fifteen years worth of course notes, and its earlier editions were extensively field-tested with students. The fourth edition includes new chapters on drug-induced carcinogensis and teratogenesis, adverse drug reactions, perinatal pharmacology, geriatric pharmacology, and behavioural pharmacology. The material on Clinical Pharmacology and Therapeutics, formerly a separate section, has been integrated into various chapters throughout the text.Table of ContentI: GENERAL PRINCIPLES; Introduction to General Pharmacology; Drug solubility, absorption, and movement across body membranes; Drug distribution; Drug biotransformation; Pharmacokinetics; Clearance, the quantitative basis of drug dosage; Drug clearance by specific organs; Dose-response relationships; Drug receptors; Specificity of drug action; Drug interactions; Human pharmacogenetics. II: AUTONOMIC NERVOUS SYSTEM AND NEUROMUSCULAR JUNCTION; Autonomic nervous system neurotransmitters; Autonomic cholinergic agonists; autonomic cholinergic antagonists; Adrenoceptor agonists; Adrenoceptor antagonists; Drugs acting on adrenergic neurons (adrenergic neuronal blocking drugs); Neuromuscular transmission and drugs (muscle relaxants). III: CENTRAL NERVOUS SYSTEM; Drugs acting on the basal ganglia; Neuron-inhibitory amino acids; anti-seizure drugs (anticonvulsants); Opioid analgesics and antagonists; General anaesthetics; Local anaesthetics; The alcohols; Anxiolytics, hypnotics and sedatives; Neuroleptics (antipsychotics); Antidepressants and lithium; Hallucinogens and psychotometics. IV: AUTACOIDS AND MEDIATORS/MODIFIERS OF TISSUE RESPONSES; Autacoids; Histamine and antihistamines; Anti-inflammatory analgesics. V: CARDIOVASCULAR SYSTEM; Digitalis glycosides; Antiarrhythmic drugs; Vasodilators, antianginal drugs, calcium channel blockers, and agents to prevent hyperlipidemia; Pharmacotherapy of hypertension. VI: RESPIRATORY, RENAL AND BLOOD SYSTEMS; Drugs and the respiratory system; Diuretics; Drugs affecting hemostasis; Hematinic drugs. VII: ENDOCRINE SYSTEMS; Vasopressin and Oxytocin; Thyroid drugs; Gonadal hormones; Insulin and oral hypoglycemic agents; Adrenocorticotropic hormone and adrenal steroids; Drugs altering bone metabolism; Vitamins. VII: GASTROINTESTINAL SYSTEM; Pharmacotherapy of gastrointestinal acid-peptic disorders; Laxatives and antidiarrheal drugs. IX: CHEMOTHERAPY; General principles of antimicrobial therapy; Antimicrobial agents which act upon bacterial cell wall formation: penicillins, cephalosporins, vancomycin, bacitracin, cycolserine; Antimicrobial and antifungal agents which act upon cell membranes: polymixins, colistin, nystatin, amphotericin B; Antimicrobial agents which affect synthesis of cellular proteins: aminoglycosides, spectinomycin, tetracyclines, chloramphenicol, erythromycin; Drugs affecting cellular nucleic acid synthesis: rifampin, nalidixic acid, griseofulvin, 5-fluorocytosine, isoniazid, ethambutol, sulfonamides, para-aminosalicylic acid, trimethoprim, pyrimethamine; Chemotherapy of common parasitic infections; Antiviral agents; Antiseptics, disinfection and sterilization; Antineoplastic drugs; Immunopharmacology. X: SPECIAL TOPICS; Drugs, alcohol and the liver; Carcinogenesis and mutagenesis by xenobiotic chemicals; Chemical teratogenesis; Adverse drug reactions; Behavioural pharmacology; Drug dependence and drug abuse;
